NAD-dependent protein deacetylase sirtuin-1 (Protein name
), SIR1_HUMAN from NCBI database.
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General Annotation
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Antigen Annotation
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Predicted Eptitope
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Gene name:
SIRT1(SIR2L1);
Protein name:
NAD-dependent protein deacetylase sirtuin-1(hSIRT1);
Alternative:
SIR2-like protein 1(hSIR2);Regulatory protein SIR2 homolog 1;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Found in a complex with PCAF and MYOD1. Interacts with FOXO1; the interaction deacetylates FOXO1, resulting in its nuclear retention and promotion of its transcriptional activity Component of the eNoSC complex, composed of SIRT1, SUV39H1 and RRP8. Interacts with HES1, HEY2 and PML. Interacts with RPS19BP1/AROS. Interacts with CCAR2 (via N-terminus); the interaction disrupts the interaction between SIRT1 and p53/TP53. Interacts with SETD7; the interaction induces the dissociation of SIRT1 from p53/TP53 and increases p53/TP53 activity. Interacts with MYCN, NR1I2, CREBZF, TSC2, TLE1, FOS, JUN, NR0B2, PPARG, NCOR, IRS1, IRS2 and NMNAT1. Interacts with HNF1A; the interaction occurs under nutrient restriction. Interacts with SUZ12; the interaction mediates the association with the PRC4 histone methylation complex which is specific as an association with PCR2 and PCR3 complex variants is not found. Interacts with HIV-1 tat. Interacts with BCL6; leads to a epigenetic repression of specific target genes.
Function:
SirtT1 75 kDa fragment: catalytically inactive 75SirT1 may be involved in regulation of apoptosis. May be involved in protecting chondrocytes from apoptotic death by associating with cytochrome C and interfering with apoptosome assembly.
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Cited for: NUCLEOTIDE SEQUENCE [MRNA];INTERACTION WITH HES1 AND HEY2;MUTAGENESIS OF HIS-363
3.
NIEHS SNPs program
Submitted (2005-11) to the EMBL/GenBank/DDBJ databases
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Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT GLU-3
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 124-747
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Cited for: FUNCTION IN DEACETYLATION OF TP53;SUBCELLULAR LOCATION;MUTAGENESIS OF HIS-363
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Cited for: FUNCTION;ENZYME ACTIVITY;SUBCELLULAR LOCATION;INTERACTION WITH PML;MUTAGENESIS OF HIS-363
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Cited for: FUNCTION IN DEACETYLATION OF FOXO3;FUNCTION IN REGULATION OF FOXO3
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Cited for: FUNCTION IN DEACETYLATION OF FOXO3;FUNCTION IN REGULATION OF FOXO3
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Cited for: FUNCTION IN DEACETYLATION OF XRCC6;INDUCTION BY CR
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Cited for: INTERACTION WITH FHL2;FUNCTION IN DEACETYLATION OF FOXO1;FUNCTION IN REGULATION OF FOXO1
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Cited for: FUNCTION IN DEACETYLATION OF MEF2D;INTERACTION WITH HDAC4
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Cited for: ASSOCIATION WITH THE PRC4 COMPLEX;INTERACTION WITH SUZ12
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-47;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: FUNCTION IN DEACETYLATION OF XRCC6;FUNCTION IN DNA REPAIR
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Cited for: FUNCTION IN DEACETYLATION OF TP73;FUNCTION IN REGULATION OF TP73
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Cited for: FUNCTION IN DEACETYLATION OF NBN;FUNCTION IN DNA REPAIR
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Cited for: IDENTIFICATION IN THE ENOSC COMPLEX;FUNCTION;MUTAGENESIS OF HIS-363
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Cited for: INTERACTION WITH HIV-1 TAT;FUNCTION IN T-CELL ACTIVATION
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Cited for: FUNCTION IN DEACETYLATION OF WRN;FUNCTION IN DNA DAMAGE
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Cited for: INTERACTION WITH CCAR2;ENZYME REGULATION;MUTAGENESIS OF HIS-363;IDENTIFICATION BY MASS SPECTROMETRY
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Cited for: PHOSPHORYLATION AT SER-14; SER-26; SER-27; SER-47; SER-159; SER-162; SER-172; SER-173; THR-530; THR-544; SER-545; THR-719 AND SER-747;MUTAGENESIS OF THR-530 AND SER-540
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-719;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: FUNCTION IN DEACETYLATION OF ATG5; ATG7 AND MAP1LC3B;FUNCTION IN AUTOPHAGY
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Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
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Cited for: PHOSPHORYLATION AT SER-659 AND SER-661;MUTAGENESIS OF SER-659; SER-661 AND SER-684
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Cited for: FUNCTION IN DEACETYLATION OF MYC;FUNCTION IN REGULATION OF MYC
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Cited for: FUNCTION IN DEACETYLATION OF PCAF;FUNCTION IN DNA REPAIR
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Cited for: PHOSPHORYLATION AT SER-27; SER-47 AND THR-530;MUTAGENESIS OF SER-27; SER-47 AND THR-530;SUBCELLULAR LOCATION
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-530; SER-535 AND THR-719;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: FUNCTION IN DNA REPAIR HOMOLOGOUS RECOMBINATION
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Cited for: FUNCTION IN DEACETYLATION OF HIF1A;FUNCTION IN REGULATION OF HIF1A
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Cited for: FUNCTION IN DEACETYLATION OF APEX1;FUNCTION IN DNA REPAIR;MUTAGENESIS OF HIS-363;INDUCTION;SUBCELLULAR LOCATION
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Cited for: ALTERNATIVE SPLICING (ISOFORM 2);FUNCTION (ISOFORM 2);INDUCTION (ISOFORM 2);INTERACTION WITH TP53 AND RPS19BP1
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Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14 AND SER-47;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: FUNCTION IN DEACETYLATION OF MYC;FUNCTION IN REGULATION OF MYC
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Cited for: FUNCTION IN APOPTOSIS;PHOSPHORYLATION AT SER-47;MUTAGENESIS OF SER-47 AND PHE-474
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Cited for: FUNCTION IN DEACETYLATION OF DNMT1;FUNCTION IN REGULATION OF DNMT1
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Cited for: FUNCTION IN REGULATION OF MYCN;INTERACTION WITH MYCN
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Cited for: INTERACTION WITH SETD7;MUTAGENESIS OF LYS-233; LYS-235; LYS-236 AND LYS-238
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Cited for: FUNCTION IN DEACETYLATION OF AKT1;FUNCTION IN REGULATION OF AKT1
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Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14; SER-47 AND THR-719;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: FUNCTION (SIRTT1 75 KDA FRAGMENT);SUBCELLULAR LOCATION (75SIRT1)
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Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: FUNCTION IN DEACETYLATION OF FOXO3;FUNCTION IN REGULATION OF FOXO3
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Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]